Dr. Chan

Dr Chee Kai Chan is Assistant Professor in the Department of Biomedical Sciences at Nazarbayev University in Astana, Kazakhstan. He completed his BSc and MEd from the National University of Singapore. He went on to complete his PhD at the John Curtin School of Medical Research at the Australian National University (1995-2000), and an A*STAR Post-doctoral Fellowship at the Johns Hopkins School of Medicine in Baltimore.

He was an Assistant Professor at the Nanyang Technological University at the National Institute of Education in Singapore. He subsequently moved to be a lecturer at the Department of Genetics at the La Trobe University in Melbourne, Australia, in 2003 until 2014 before moving to Nazarbayev University.

He has a passion for Human and Medical Genetics Education. For his contribution to Teaching and Learning he received the Faculty of Science, Engineering and Technology Citation Award in 2007. He was also active as a Genetics Director in an Australian based company called Fitgenes Pty Ltd from 2008-2014 where he presently remains as a consultant on the company’s Scientific Advisory Committee.

Publications

Chee Kai Chan & Daniel Torrano. 1^st year Medical students’ learning style preference and their correlation with performance in different subjects within the medical course. BMC Medical Education.2017. 17(1) 131.

Chee Kai Chan, Paul Beaver, Ayana Arystan, Kathryn Goozee, Ralph Martins. 2015. Application of nutrigenomics for personalized intervention of Alzheimer’s disease and metabolic syndrome. The Herald of the Medical Center of President’s affairs administration of the republic of Kazakhstan 2015; 1(58): 58-60.

C McDermott, S Diepstraten, J Vadolas, B McColl, CK Chan, A Hart. 2015. Reactivation of gamma-globin using CRISPR-CAS9 as a potential gene therapy for beta-thalassemia. Journal of Gene Medicine 17 (8-9), 214-214

S Diepstraten, J Vadolas, B McColl, CK Chan, A Hart 2015. A Novel system for analysis and manipulation of Human Globin gene switching in vitro. Journal of Gene Medicine 17 (8-9), 206-206

Stephen R Doyle, Ph.D.; Naga R.P. Kasinadhuni; Chee Kai Chan; Warwick N Grant (2013) Evidence of evolutionary constraints that influences the sequence composition and diversity of mitochondrial matrix targeting signals. PLos ONE 8(6). e67938.doi:10.1371/journal.pone.0067938.

Duy Huynh; Dilara Akcora; Jordane Malaterre; Chee-Kai Chan; Xu-Ming Dai; Ivan Bertoncello; E. Richard Stanley; Robert George Ramsay (2013) CSF1 Receptor-Dependent colon development, homeostasis and inflammatory stress response. PLoS ONE 8 (2) e56951.doi:10.1371/journal.pone.0056951

Stephen R Doyle, Chee Kai Chan and Warwick Grant (2011) Enhanced annealing of mismatched oligonucleotides using a novel melting curve assay allows efficient in vitro discrimination and restriction of a single nucleotide polymorphism. BMC Biotechnology, 11:83doi:10.1186/1472-6750-11-83

Chee Kai Chan, Adam Hart, Anna Lister, Stephen Doyle (2011). Learning styles of 3^rd year Genetics Students and their Affection and Perception of effectiveness of a range of Instructional Modes. Proceedings of the Australian Conference on Science and mathematics Education. 121.

Michal Ugarenko, Chee-Kai Chan, Abraham Nudelman, Ada Rephaeli, Suzanne M Cutts, Don R Phillips (2009). Development of pluronic micelle-encapsulated doxorubicin and formaldehyde-releasing prodrugs for localized anticancer chemotherapy. Oncology Research. 17(7): 283-99

Duy Huynh, Xu-Ming Dai, Sayan Nandi, Sally Lightowler, Melanie Trivett, Chee-Kai Chan, Ivan Bertoncello, Robert G Ramsay, E Richard Stanley. (2009) Colony stimulating factor-1 dependence of paneth cell development in the mouse small intestine. Gastroenterology. 137(1): 136-44, 144.

Stephen R Doyle, Chee Kai Chan (2008). Mitochondrial gene therapy: an evaluation of strategies for the treatment of mitochondrial DNA disorders. Human Gene Therapy. Dec;19(12): 1335-48

Stephen R Doyle, Chee Kai Chan (2007). Differential intracellular distribution of DNA complexed with polyethylenimine (PEI) and PEI-polyarginine PTD influences exogenous gene expression within live COS-7 cells. Genetic Vaccines and Therapy. 5: 11

Duy D. Huynh, E. Vincan, T. Mantamadiotis, D. Purcell, CK Chan R. Ramsay (2007) Oncogenic properties of HIV-Tat in colorectal cancer cells. Current HIV Research, 5(4): 403-9.

Tania Blanksby & Chee Kai Chan (2006) Feedback assessment of Science report writing for first year Genetics students . UNISERVE Symposium, Assessment in Science Teaching and Learning. 161.

Loveland, A.N. Chee-Kai Chan, Edward J. Brignole and Wade Gibson (2005) Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity. J Virol 79 (20), 12961-12968

Duy K. Pham and Chee Kai Chan. (2005) Impact of Polymeric Surfaces on Oligonucleotides Immobilization for Lab-On-A-Chip Applications, Trends in DNA Research (Nova Science Publishers) Edit: Corey Woods

Chan, C.K. et al. (2002) Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions. J Virol 76 (17), 8667-8674

Chan, C.K. and Jans, D.A. (2002) Using nuclear targeting signals to enhance non-viral gene transfer. Immunol Cell Biol 80 (2), 119-130

Chan, C.K. and Jans, D.A. (2001) Enhancement of MSH receptor- and GAL4-mediated gene transfer by switching the nuclear import pathway. Gene Ther 8 (2), 166-171

Chan, C.K. et al. (2000) Supramolecular structure and nuclear targeting efficiency determine the enhancement of transfection by modified polylysines. Gene Ther 7 (19), 1690-1697

Hubner, S. et al. (1999) Plant importin alpha binds nuclear localization sequences with high affinity and can mediate nuclear import independent of importin beta. J Biol Chem 274 (32), 22610-22617

Chan, C.K. and Jans, D.A. (1999) Enhancement of polylysine-mediated transferrinfection by nuclear localization sequences: polylysine does not function as a nuclear localization sequence. Hum Gene Ther 10 (10), 1695-1702

Chan, C.K. and Jans, D.A. (1999) Synergy of importin alpha recognition and DNA binding by the yeast transcriptional activator GAL4. FEBS Lett 462 (1-2), 221-224

Jans, D.A. et al. (1998) Signals mediating nuclear targeting and their regulation: application in drug delivery. Med Res Rev 18 (4), 189-223

Chan, C.K. et al. (1998) Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: implications for nonviral DNA delivery. Gene Ther 5 (9), 1204-1212

Goh NK, Chan CK & Chia LS. (1995). A comparison of the differences of two teaching strategies in the modification of students misconceptions in science. ACCESS , 13(2); 161-171.

Goh NK, Chan CK & Chia LS. (1995). Gender differences, misconceptions and instruction in Science. Singapore J. Edu. 15: 33-41.

Positions